A comprehensive analysis of RNA sequences reveals macroscopic somatic clonal expansion across normal tissues
Keren Yizhak, François Aguet, Jaegil Kim, Julian M. Hess, Kirsten Kübler, Jonna Grimsby, Ruslana Frazer, Hailei Zhang, Nicholas J. Haradhvala, Daniel Rosebrock, Dimitri G. Livitz, Xiao Li, Eila Arich-Landkof, Noam Shoresh F, Chip Stewart, , Gad A. Getz
This study analyzes RNA-seq data from 6,700 normal tissues to identify somatic mutations and their association with age and tissue proliferation, finding tissue-specific cancer mutation hotspots.
Science · Jun 6, 2019Peer-reviewedGenomics