Kirsten Kübler

Endometriosis lesions are oligoclonal structures derived from the normal endometrium

This study shows endometriosis lesions originate from the normal endometrium through clonal expansion, with distinct clones at different body sites.

commonPeak: Equivalence testing to identify common ChIP-seq peaks across conditions and protocols

commonPeak identifies common ChIP-seq peaks across conditions and protocols using equivalence testing, finding 225 shared estrogen receptor peaks with similar enrichment in breast cancer cells.

COOBoostR: an extreme gradient boosting-based tool for robust tissue or cell-of-origin prediction of tumors

COOBoostR uses extreme gradient boosting to predict tumor tissue or cell-of-origin using chromatin marks and mutation density data, outperforming random forest methods in speed and accuracy.

Genome-wide mutational signatures of immunological diversification in normal lymphocytes

The paper analyzes the mutational landscape of normal lymphocytes, revealing off-target effects of programmed genome engineering and the impact of differentiation and microenvironment exposure.

A comprehensive analysis of RNA sequences reveals macroscopic somatic clonal expansion across normal tissues

This study analyzes RNA-seq data from 6,700 normal tissues to identify somatic mutations and their association with age and tissue proliferation, finding tissue-specific cancer mutation hotspots.

Tumor mutational landscape is a record of the pre-malignant state

The paper predicts cancer cell-of-origin from DNA sequences by matching mutational landscapes to chromatin modification patterns in normal tissues.