Autophagy in DG engrams mediates Rac1-dependent forgetting via TLR2/4 signals in microglia
Zhilin Wang, Ruyan Chen, Qing Lin, Yan ping Jiang, Qiumin Le, Xing Liu, Lan Ma, Feifei Wang
This study identifies a pathway where Rac1 increases autophagy in DG engrams, activates microglia via TLR2/4, and promotes forgetting through synapse remodeling.
bioRxiv · Aug 26, 2021 · PreprintNeuroscience