Modulation of specific interactions within a viral fusion protein predicted from machine learning blocks membrane fusion
Ryan E. Odstrcil, Albina O. Makio, McKenna A. Hull, Prashanta Dutta, Anthony V. Nicola, Jin Liu
The paper identifies a critical polar interaction in the viral fusion protein gB using machine learning and experiments, showing its role in stabilizing the pre-fusion conformation and blocking membrane fusion.
Nanoscale · Jan 1, 2025Peer-reviewedMicrobiology