Anthony V. Nicola

This study examines the antigenic differences between a prefusion and wild-type form of HSV-1 gB, finding distinct antigenic profiles and suggesting pH-induced conformational changes.

This study shows HSV-1 gC shields gD from neutralizing antibodies, increasing viral susceptibility to antibody neutralization when gC is absent.

The paper identifies a critical polar interaction in the viral fusion protein gB using machine learning and experiments, showing its role in stabilizing the pre-fusion conformation and blocking membrane fusion.