Connecting the sequence-space of bacterial signaling proteins to phenotypes using coevolutionary landscapes
Ryan R. Cheng, Olle Nordesjö, Ryan L. Hayes, Herbert Levine, Samuel C. Flores, José N. Onuchic, Faruck Morcos
The paper constructs a Potts model to predict how mutations affect TCS protein interactions and validates it against experimental data on PhoQ kinase variants.
Molecular Biology and Evolution · Sep 7, 2016Peer-reviewedBiophysics