Integrated Proteomic and Metabolomic Analyses of the Mitochondrial Neurodegenerative Disease MELAS
Haorong Li, Martine N. Uittenbogaard, Ryan Navarro, Mustafa Jamal Ahmed, Andrea Lynne Gropman, Anne Chiaramello, Ling Hao
This study integrates proteomic and metabolomic analyses of patient-derived fibroblasts to identify dysregulated pathways in MELAS, revealing OXPHOS defects and arginine biosynthesis downregulation.
Molecular Omics · Dec 21, 2021Peer-reviewedSystems Biology