Biological Network Organization, Not Generic Graph Topology, Drives Graph-Based Gene Essentiality Prediction
Setareh Rahimi, S M Bonner, Avid M. Afzal, Marta Milo, Edward Morrissey, Evangelia Petsalaki
This study evaluates whether graph-based gene essentiality prediction relies on biological network structure or generic graph topology, finding that biological connectivity is critical for performance.
bioRxiv · Jul 4, 2026 · PreprintSystems Biology