A Mouse Model of the Protease Activated Receptor 4 (PAR4) Pro310Leu Variant has Reduced Platelet Reactivity
X. Han, E. A. Knauss, M. de la Fuente, W. Li, R. A. Conlon, D. F. LePage, W. Jiang, S. A. Renna, S. E. McKenzie, M. T. Nieman
This study creates a mouse model of the PAR4-P310L variant and shows reduced platelet reactivity to PAR4-activation peptide and thrombin, with no effect on ADP and convulxin responses.
bioRxiv · Dec 1, 2023Physiology