Cell BiologybioRxiv
Topological stress triggers persistent DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment
A. Urbancokova, T. Hornofova, J. Novak…·P. Vasicova
This study shows that topological stress and RNAPI inhibition cause rDNA damage, leading to PML-nucleolar compartments (PNAs) that help prevent rDNA instability and may contribute to aging and cancer.
DOI 10.7554/elife.91304