Topological stress triggers persistent DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment
A. Urbancokova, T. Hornofova, J. Novak, S. A. Salajkova, S. Stemberkova Hubackova, A. Uvizl, T. Buchtova, M. Mistrik, B. Mac Stay, Z. Hodny, J. Bartek, P. Vasicova
This study shows that topological stress and RNAPI inhibition cause rDNA damage, leading to PML-nucleolar compartments (PNAs) that help prevent rDNA instability and may contribute to aging and cancer.
bioRxiv · Aug 5, 2023Cell Biology