S. C. C. Hsueh

De novo design of a β-helix tau protein scaffold: An oligomer-selective vaccine immunogen candidate for Alzheimer's disease

This paper designs a β-helix tau protein scaffold that mimics toxic tau oligomers and shows selective binding to antibodies, suggesting it could be an effective vaccine immunogen for Alzheimer's disease.

PROTHON: A Local Order Parameter-Based Method for Efficient Comparison of Protein Ensembles

PROTHON efficiently compares protein conformational ensembles using local order parameters, outperforming ENCORE in speed and resource usage.

Predicting the feasibility of targeting a conserved region on the S2 domain of the SARS-CoV-2 spike protein

The paper assesses the feasibility of targeting a conserved S2 epitope on the SARS-CoV-2 spike protein, finding it unlikely to be exposed without external factors and suggesting it may be a viable therapeutic target.

Accelerated ensemble generation for cyclic peptides using a Reservoir-REMD implementation in GROMACS

This paper implements and benchmarks Res-REMD in GROMACS for cyclic peptide ensemble generation, showing it accelerates sampling for some systems but not others.

Optimizing epitope conformational ensembles using α-synuclein cyclic peptide "glycindel" scaffolds: A customized immunogen method for generating oligomer-selective antibodies for Parkinson's disease