Heterozygous Cell Models of STAT1 Gain-of-Function Reveal a Broad Spectrum of Interferon-Signature Gene Transcriptional Responses
O. Scott, K. Lindsay, S. Erwood, C. M. Roifman, R. D. Cohn, E. A. Ivakine
This study uses CRISPR/Cas9 to create heterozygous STAT1 gain-of-function models in HAP1 cells, revealing diverse transcriptional responses to interferon stimulation.
bioRxiv · Nov 9, 2020Immunology