Structural basis for the ARF GAP activity and specificity of the C9orf72 complex
M.-Y. Su, S. H. Fromm, J. Remis, D. Toso, J. H. Hurley
The paper determines the cryo-EM structure of the C9orf72 complex bound to ARF1-GDP-BeF3, revealing its specific GAP activity toward ARF1 and lower efficiency toward RAB8A.
bioRxiv · Apr 13, 2021Biochemistry