The Interplay of Electrostatics and Chemical Positioning in the Evolution of Antibiotic Resistance in TEM β-Lactamases
S. H. Schneider, J. Kozuch, S. G. Boxer
The paper analyzes the evolutionary trajectory of TEM β-lactamases to understand how electrostatics and chemical positioning contribute to antibiotic resistance and catalytic function.
bioRxiv · May 27, 2021Biophysics