SOX2-phosphorylation toggles a bistable differentiation-switch in squamous cell carcinoma
S. Hoang-Phou, A. Sastre-Perona, M. Abbruzzese, Z. Ying, J. Siegle, B. Aranda Orgilles, P. P. Rocha, I. Aifantis, J. Skok, S. Beronja, M. Schober
This paper identifies a mechanism by which SOX2-phosphorylation toggles a bistable differentiation switch in squamous cell carcinoma, enabling tumor-propagating cells to transition from self-renewal to differentiation.
bioRxiv · Aug 18, 2021 · PreprintCancer Biology