Understanding the antiviral effects of RNAi-based therapy on chronic hepatitis B infection
S. M. Ciupe, H. Dahari, S. Kadelka
This paper develops a pharmacokinetic-pharmacodynamic model to analyze the antiviral effects of ARC-520 and entecavir on HBV DNA, HBsAg, and HBeAg in patients, showing high initial efficacy of ARC-520 and sustained efficacy of entecavir.
bioRxiv · Jul 21, 2020Immunology