S. L. Fong

Function and constraint in enhancers with multiple evolutionary origins

The paper analyzes the function and evolutionary constraints of core and derived sequences in complex human enhancers, finding distinct regulatory roles and constraint profiles.

Modeling the evolutionary architectures of human enhancer sequences reveals distinct origins, functions, and associations with human-trait variation

The paper models human enhancer sequence evolution, identifying simple and complex architectures and their associations with trait variation.

Accounting for diverse evolutionary forces reveals the mosaic nature of selection on genomic regions associated with human preterm birth

The paper develops an approach to analyze evolutionary forces on genomic regions linked to preterm birth and finds diverse signatures like negative and positive selection.