G. Zhang

Follow-up availability and the robustness of immune transcriptomic recovery after myocardial infarction

The paper assesses the robustness of immune transcriptomic recovery after myocardial infarction by evaluating how missing data and assay availability affect inflammatory-response scores over time.

AMHY and sex determination in egg-laying mammals

This study identifies AMHY as the primary male sex determination gene in monotremes by analyzing its expression and function during sexual differentiation.

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19

The paper identifies a potent orally bioavailable SARS-CoV-2 PLpro inhibitor with in vitro and in vivo antiviral activity against SARS-CoV-2 and related coronaviruses.

A Combinatorial Strategy for HRV 3C Protease Engineering to Achieve the N-terminal Free Cleavage

This paper develops a combinatorial strategy to engineer HRV 3C protease for N-terminal free cleavage by expanding P1 specificity through structure-guided library design and high-throughput screening.

Selective dissociation of vacant 70S ribosomes by RsfS promotes bacterial adaptation to nutrient starvation

This study shows RsfS selectively dissociates vacant 70S ribosomes during nutrient starvation, improving bacterial survival by conserving energy.

Evolutionary trajectory of TRPM2 channel activation by adenosine diphosphate ribose and calcium

The paper traces the evolutionary changes in TRPM2 channel activation mechanisms across species, identifying key stages in the transition from simple to complex ligand binding and calcium gating.

Novel Ser74 of NF-kappaB/CgIkappaBalpha Phosphorylated by MAPK/ERK Regulates Temperature Adaptation in Oysters

The paper identifies a novel phosphorylation site (Ser74) in oyster NF-kappaB/CgI{kappa}B regulated by MAPK/ERK that mediates thermal adaptation through ubiquitin-proteasome degradation and nuclear translocation of CgREL.

Efficient cloning of genes for wheat yield component traits from QTLs via sequencing of the RIL population

This study develops a method to clone genes for wheat yield traits by sequencing RIL populations, identifying and validating 11 candidate genes from 77 QTLs.

Metagenomic, metabolomic, and lipidomic shifts associated with fecal microbiota transplantation for recurrent Clostridioides difficile infection

This study examines changes in microbiome, metabolome, and lipidome after fecal microbiota transplantation for recurrent C. difficile infection, identifying lipid and bile acid shifts linked to treatment success.

XKidneyOnco: An Explainable Framework to Classify Renal Oncocytoma and Chromophobe Renal Cell Carcinoma with a Small Sample Size

This study introduces an explainable AI framework to differentiate renal oncocytoma from chromophobe renal cell carcinoma with high accuracy, outperforming human experts in some metrics.

Balancing stability, dynamics and kinetics in phase separation of intrinsically disordered proteins

This study investigates the thermodynamics and kinetics of phase separation in intrinsically disordered proteins using a coarse-grained model, revealing a non-monotonic relationship between interaction strength and condensate formation rates.

Changes in physicochemical properties and microbial community succession during leaf stacking fermentation

This study examines changes in physicochemical properties and microbial communities during leaf stacking fermentation, identifying key metabolites and microbial interactions.

USP7 Inhibition Promotes Early Osseointegration in Senile Osteoporotic Mice

This study shows that USP7 inhibition accelerates osseointegration in senile osteoporotic mice by enhancing macrophage efferocytosis and inducing apoptosis in aged BMSCs.

Neurophysiological Features of STN LFP underlying Sleep Fragmentation in Parkinson's Disease

This study identifies STN LFP features, including beta and gamma oscillations and the low-high power ratio, that correlate with sleep fragmentation in Parkinson's disease patients.

New insights into tissue-specific responses and interactive characteristics of crop-microbe "One Health" system to soil chromium and ofloxacin pollution

This study examines how ginger and soil microbes respond to combined chromium and ofloxacin pollution, revealing hormesis effects, microbial shifts, and risks in the food chain.

Multiscale effects of perturbed translation dynamics inform antimalarial design

The paper determines in situ structures of Pf80S ribosomes in Plasmodium falciparum-infected erythrocytes, identifies a bifurcation in translation elongation, and links perturbations to inhibitor effects on ribosome interactions.

Casein kinase II promotes piRNA production through direct phosphorylation of USTC component TOFU-4

This study identifies casein kinase II (CK2) as a regulator of piRNA production by phosphorylating TOFU-4, a component of the USTC complex, and shows its role in aging-related piRNA silencing defects.

Functional analysis of Cdc20 reveals a critical role of CRY box in mitotic checkpoint signaling

This study functionally analyzes Cdc20's role in mitotic checkpoint signaling by identifying the CRY box's critical role in SAC through MCC formation and APC/C interaction.

Carbonate dissolution without acid: carbonate hydrolysis, catalyzed by photosynthetic microorganisms, in deteriorating stone monuments

The paper investigates carbonate dissolution in stone monuments caused by photosynthetic microorganisms, finding evidence of cyanobacterial biofilms and mineral dissolution patterns consistent with their activity.

Identifying Membrane Protein-Lipid Interactions with Lipidomic Lipid Exchange-Mass Spectrometry

This paper introduces a method to identify lipid-protein interactions using lipidomic lipid exchange-mass spectrometry and applies it to study three membrane proteins.

Synchrony of Bird Migration with Avian Influenza Global Spread; Implications for Vulnerable Bird Orders

The paper uses phylodynamic analyses to link bird migration patterns with the global spread of HPAIV H5 clade 2.3.4.4, identifying vulnerable bird orders and highlighting Suliformes and Ciconiiformes as important in virus dispersal.

p300 Is an Obligate Integrator of Combinatorial Transcription Factor Inputs

This study shows p300 requires multiple transcription factor interaction domains for chromatin binding and catalytic regulation, highlighting the necessity of combinatorial TF inputs for coactivator function.

Genome-wide association and environmental suppression of the mortal germline phenotype of wild C. elegans

This study identifies a genetic basis for a mortal germline phenotype in wild C. elegans and shows that environmental factors and non-genetic memory can suppress it.

Discovery of microsized RNA-derived RNAs and polypeptides in human cells

The paper discovers a new RNA-to-polypeptide pathway involving msRNAs, msdRs, and msdPs, with potential cancer-related applications.

Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas

This study shows that ATRX loss primes glioma cells for innate immune recognition, while IDH1R132H mutation suppresses immune signaling, which can be reversed by IDH1 inhibition.

Characterization of Tryptophan Oxidation Affecting D1 Degradation by FtsH in the Photosystem II Quality Control of Chloroplasts

This study shows that Trp oxidation at the N-terminus of D1 protein enhances FtsH-mediated degradation during high-light stress in PSII repair.

Targeting MCL1-driven anti-apoptotic pathways to overcome hypomethylating agent resistance in RAS-mutated chronic myelomonocytic leukemia

This study identifies MCL1 as a survival factor in RAS-mutated CMML, explaining resistance to BCL2 inhibitors and suggesting new therapeutic targets.

Reversing myeloid-derived suppressor cells mediated immunosuppression via p38α inhibition enhances immunotherapy efficacy in triple negative breast cancer

This study shows that p38α inhibition reduces immunosuppression by MDSCs and enhances immunotherapy in TNBC by decreasing CXCL1/CXCL2 expression.

The maize PLASTID TERMINAL OXIDASE (PTOX) gene controls the carotenoid content of kernels.

This study identifies ZmPTOX1 as a key gene for carotenoid biosynthesis in maize kernels, showing that its disruption reduces carotenoid content while overexpression increases it, particularly beta-carotene.