Mutated neuronal voltage-gated CaV2.1 channels causing familial hemiplegic migraine 1 increase the susceptibility for cortical spreading depolarization and seizures and worsen outcome after experimental traumatic brain injury
Nicole A. Terpolilli, R. Dolp, K. Waehner, S. M. Schwarzmaier, E. Török, Boyan Todorov, Michel Dominique Ferrari, Arn M.J.M. van den Maagdenberg, Nikolaus Plesnila
This study shows that FHM1 mutations in CaV2.1 channels worsen outcomes after TBI by increasing CSDs, seizures, and brain edema in mice.
eLife · Mar 3, 2022Peer-reviewedNeuroscience