Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma
S. M.-L. Lauer, M. H. Omar, M. G. Golkowski, H. L. Kenerson, B. C. Pascual, K. Forbush, F. D. Smith, J. Gordan, S.-E. M. Ong, R. S. Yeung, J. D. Scott
This study identifies BAG2 as a key player in DNAJ-PKAc-mediated chemotherapeutic resistance in fibrolamellar carcinoma by linking it to Hsp70 and Bcl-2.
bioRxiv · Jun 28, 2023Cancer Biology