Comprehensive analysis of mutational signatures in pediatric cancers
V. Thatikonda, S. M. A. Islam, B. C. Jones, S. N. Groebner, G. Warsow, B. Hutter, D. Huebschmann, S. Froehling, M. Blattner-Johnson, D. T. W. Jones, L. B. Alexandrov, S. M. Pfister, N. Jaeger
This study analyzes mutational signatures in pediatric cancers, finding fewer active signatures compared to adult cancers and linking specific signatures to TP53 mutations and chromothripsis.
bioRxiv · Sep 28, 2021Cancer Biology