L. B. Alexandrov

The paper shows that mitotic tethering by MDC1, TOPBP1, and CIP2A enables en masse inheritance of chromothriptic chromosome fragments, contributing to cancer genome evolution.

This study shows arsenic enhances UVR-induced skin cancer and mutagenesis, identifying a unique mutational signature from co-exposure.

This paper analyzes how mutational signatures in cancer genomes are influenced by genomic topography using integrated data from 5,120 tumors and ENCODE features.

This study analyzes mutational signatures in pediatric cancers, finding fewer active signatures compared to adult cancers and linking specific signatures to TP53 mutations and chromothripsis.

The paper analyzes clustered mutations in 2,583 cancer genomes, identifying APOBEC3-driven mutagenesis on ecDNA as a significant contributor to cancer evolution.

This paper identifies 19 copy number signatures in 9,873 cancers, explaining 93% of TCGA samples, and reveals diverse mechanisms underlying copy number alterations in human cancer.

This study shows UV-nail polish dryer radiation causes DNA damage and somatic mutations in mammalian cells, with mutagenic patterns linked to reactive oxygen species.

This paper develops a syngeneic mouse model of tobacco-associated HNSCC that shows high response rates to anti-CTLA-4 therapy.

The paper shows PMDs are hypervariable in breast cancer and drive CGI hypermethylation, but do not significantly repress cancer genes.