Cancer BiologybioRxiv
Validation of a small molecule inhibitor of PDE6D-RAS interaction with potent anti-leukemic effects
S. C. Nunes, S. De Vita, A. Anighoro…·H. Xu
The paper identifies a small molecule inhibitor of PDE6D-RAS interaction that shows anti-leukemic effects by blocking RAC activation in RAS-mutated cells.
DOI 10.1038/s41408-022-00663-z