Cancer BiologybioRxiv
Nucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinoma.
A. Prosz, H. Duan, V. Tisza…·Z. Szallasi
This paper identifies NER deficiency as a targetable vulnerability in ccRCC, showing that 10% of patients may respond to irofulven based on mutational signatures and PTGR1 expression.
DOI 10.1038/s41598-023-47946-4