Conformational flexibility is a key determinant of the lytic activity of the pore forming protein, Cytolysin A
A. Kulshrestha, S. Maurya, T. Gupta, R. Roy, S. Punnathanam, K. G. Ayappa
This study shows that conformational flexibility in the β-tongue and N-terminus regions of ClyA is essential for its lytic activity and membrane-mediated conformational transition.
bioRxiv · Oct 23, 2021 · PreprintBiophysics