Loss of cholesterol in Junctional Epidermolysis Bullosa skin identifies a key role for Laminin-332 in actomyosin mediated cholesterol transport
E. M. Jones, E. Camera, P. Parzymies, S. T. Marsh, R. F. O'Shaughnessy, M. Aumailley, J. A. McGrath, E. A. O'Toole, M. P. Caley
This study shows that loss of Laminin-332 in JEB disrupts cholesterol transport in keratinocytes, affecting epidermal lipid metabolism and barrier function.
bioRxiv · Sep 10, 2023 · PreprintCell Biology