ImmunologybioRxiv
The CC′ loop of IgV domain containing immune checkpoint receptors: From a bystander to an active determinant of receptor:ligand binding
S. V. Kundapura, U. A. Ramagopal
The paper identifies the CC′ loop of IgV domains as a critical region for affinity modulation in immune checkpoint receptor:ligand interactions, showing its role in binding without affecting specificity.
DOI 10.1038/s41598-019-54623-y