Structure, dynamics and roX2-lncRNA binding of tandem double-stranded RNA binding domains dsRBD1,2 of Drosophila helicase Maleless
P. K. A. Jagtap, M. Mueller, P. Masiewicz, S. von Buelow, N. M. Hollmann, B. Simon, A. W. Thomae, P. B. Becker, J. Hennig
This study determines the NMR structure of MLE's dsRBD1 and dsRBD2 and shows they bind dsRNA independently, but dsRBD1 mutants do not affect roX2 binding or MLE localization.
bioRxiv · Nov 9, 2018Biochemistry