ProSAAS is Preferentially Secreted from Neurons During Homeostatic Scaling and Reduces Amyloid Plaque Size in the 5xFAD Mouse Hippocampus
Samira Mitias, Nicholas Schaffer, Saaya Nair, Chelsea Hook, Iris Lindberg
The paper investigates proSAAS's role in homeostatic scaling and its effect on amyloid plaques in 5xFAD mice, finding increased secretion and reduced plaque size with proSAAS overexpression.
bioRxiv · Apr 18, 2024 · PreprintNeuroscience