Iris Lindberg

The paper determines the structure of an immature proPC1/3 variant and identifies a conformational checkpoint for ER export, explaining the functional impact of PCSK1 mutations.

This study identifies SEL1L-HRD1 ERAD as a regulator of PC2 maturation and glucagon production in islet α cells by degrading misfolded proPC2.

The paper investigates proSAAS's role in homeostatic scaling and its effect on amyloid plaques in 5xFAD mice, finding increased secretion and reduced plaque size with proSAAS overexpression.

This study shows that cytoplasmic proSAAS forms liquid-like condensates that sequester TDP-43 aggregates, providing cytoprotection against toxicity in yeast.

This paper demonstrates that proSAAS overexpression protects dopaminergic neurons and reduces transsynaptic α-synuclein spread in Parkinson's disease models.

This paper introduces a protease protection assay to distinguish internalized alpha-synuclein PFFs from surface-bound ones using TEV protease.