Combined kinome inhibition states are predictive of cancer cell line sensitivity to kinase inhibitor combination therapies
Chinmaya U. Joisa, Kevin A. Chen, Samantha Beville, Timothy Joseph Stuhlmiller, Matthew E. Berginski, Denis O. Okumu, Brian T. Golitz, Gary L. Johnson, Shawn M. Gomez
The paper predicts cancer cell line sensitivity to kinase inhibitor combinations using kinome inhibition states and machine learning, achieving high accuracy in both simulated and experimental settings.
bioRxiv · Aug 1, 2023 · PreprintSystems Biology