Denis O. Okumu

Vulnerability of triple negative breast cancer to daraxonrasib pan-RAS(on) inhibition

This study shows that daraxonrasib, a pan-RAS(on) inhibitor, effectively inhibits TNBC cell proliferation and tumor growth, either alone or in combination with a MEK inhibitor.

Transcriptomic profiling of mouse mammary tumors enables prognostic and predictive biomarker discovery for human breast cancers

This paper uses mouse mammary tumor data to train machine learning models predicting human breast cancer survival and treatment response.

Kinase Plasticity in Response to Vandetanib Enhances Sensitivity to Tamoxifen in Estrogen Receptor Positive Breast Cancer

This study shows vandetanib enhances tamoxifen sensitivity in ER+ breast cancer by reprogramming ER gene regulation and kinase networks, identifying adaptive resistance pathways and response signatures.

Quantitative proteomic mass spectrometry of protein kinases to determine dynamic heterogeneity of the human kinome

This study quantifies kinase protein abundance in human tissues using proteomic mass spectrometry, revealing heterogeneity in breast cancer subtypes and enabling clinical applications.

Combined kinome inhibition states are predictive of cancer cell line sensitivity to kinase inhibitor combination therapies

The paper predicts cancer cell line sensitivity to kinase inhibitor combinations using kinome inhibition states and machine learning, achieving high accuracy in both simulated and experimental settings.