Structural characterization of human endogenous retrovirus integration and strand transfer inhibition
Ane Barrena-Martin, Sandra Fuertes, Manuel Daza-Martín, Guillermo Abascal-Palacios
This study determines the structural states of hERV-K integration machinery using cryo-EM and biochemical assays, revealing a compact tetrameric structure and a novel drug-induced conformation.
bioRxiv · Jun 26, 2026 · PreprintBiophysics