The HDAC inhibitor CI-994 acts as a molecular memory aid by facilitating synaptic and intra-cellular communication after learning
Allison M. Burns, Mélissa Farinelli-Scharly, Sandrine Hugues, Jose Vicente Sanchez-Mut, Giulia Santoni, Johannes Gräff
This study shows that the HDAC inhibitor CI-994 enhances memory formation in mice by promoting synaptic plasticity and transcriptional changes in the hippocampus when combined with fear conditioning.
Proceedings of the National Academy of Sciences · May 25, 2022Peer-reviewedNeuroscience