Johannes Gräff

This study investigates how remote fear memory generalization occurs through increased recruitment of engrams in the medial prefrontal cortex, mediated by ventral hippocampal inputs.

This study uses CRISPR-based epigenetic editing in adult mouse brains to show that site-specific epigenetic changes in learning-related neurons are causally involved in memory expression.

ABBA and BraiAn tools enable whole-brain mapping of immediate early genes, revealing distinct expression patterns across brain regions and behavioral conditions.

The paper introduces LOOMINA, an optogenetic system that deactivates transcriptional activation in response to blue light, offering high adaptability and compatibility with various effector proteins.

The paper identifies spatiotemporal shifts in prelimbic cortex inputs during early fear memory consolidation using retrograde tracing and chemogenetic inhibition.

This study shows that the HDAC inhibitor CI-994 enhances memory formation in mice by promoting synaptic plasticity and transcriptional changes in the hippocampus when combined with fear conditioning.