Single-domain antibodies targeting the pan-T-cell markers CD2 and CD7 as universal immunotherapy T-cell tracers
Dario Gosmann, Lisa Russelli, Theresa Käsbauer, Sandro Bissenberger, Florian Bassermann, Wolfgang Weber, Calogero D’Alessandria, Angela M. Krackhardt
This paper develops two single-domain antibody-based PET tracers targeting CD2 and CD7 to visualize T cells in vivo without affecting their function, offering a tool for monitoring immunotherapy responses.
bioRxiv · Dec 25, 2025 · PreprintImmunology