RobPicker: A Meta Learning Framework for Robust Identification of Macromolecules in Cryo-Electron Tomograms
Ramtin Hosseini, Youwei Liang, Digvijay Singh, Hamidreza Rahmani, Sang Choe, Joan Lee, Min Xu, Eran Segal, James Zou, James R. Williamson, Danielle Ann Grotjahn, Elizabeth Villa, Pengtao Xie
RobPicker improves macromolecule identification in cryo-ET by addressing label noise and class imbalance through a meta-learning framework, outperforming existing methods in detecting small and rare species.
bioRxiv · Sep 16, 2025 · PreprintBioinformatics