Elizabeth Villa

This study identifies Rhc as a multifunctional protein essential for DNA replication and transcription in nucleus-forming phages, revealing its role in resolving R-loops and coordinating gene expression.

This study identifies a unique DNA replication mechanism in the chimallivirus PhiKZ, where a sliding clamp-derived protein enhances polymerase activity through a transient interaction.

This study uses in-cell cryo-electron tomography to compare how type I and type II kinase inhibitors affect LRRK2-I2020T filament formation and microtubule association in cells.

This study characterizes the molecular architecture of tunneling nanotubes (TNTs) using live-cell imaging and cryo-ET, revealing a complex structure with actin, microtubules, and organelles.

The paper identifies CapK and CapS proteins that regulate immune operon expression in response to DNA damage in bacteria.

The paper investigates the structure of chromatin condensates across scales and shows how nucleosome arrangement and histone interactions influence their physical properties.

This paper introduces nanogold probes for identifying proteins in live cells and cryo-ET tomograms, enhancing proteome accessibility for electron microscopy.

RobPicker improves macromolecule identification in cryo-ET by addressing label noise and class imbalance through a meta-learning framework, outperforming existing methods in detecting small and rare species.

The paper develops methods to analyze chromatin condensates using cryo-electron tomography and deep learning, revealing nucleosome structures and interactions in both reconstituted and native systems.

This study uses molecular dynamics simulations to show that N-linked glycans at positions N88 and N611 modulate HIV-1 Env tilting motion in a membrane environment.

The paper studies a phage lacking PhuZ, showing it replicates efficiently without this protein, highlighting variation in nucleus-based replication pathways.

ProteinAligner improves protein function and property prediction by integrating sequence, structure, and literature text modalities in a multi-modal pretraining framework.

This study uses cryo-ET to show that LRRK2 can form microtubule-bound filaments in its autoinhibited state, with structural differences compared to active-LRRK2 filaments.

ProteinChat is a multi-modal large language model that predicts protein functions from amino acid sequences, outperforming general-purpose LLMs and task-specific models.

This study uses structural biology to reveal the architecture of the nuclear basket in yeast and mammals, showing how Mlp/Tpr proteins form its structural components.

This paper identifies components of a novel protein import pathway in phages, revealing a mechanism for selective protein trafficking into the phage nucleus.