History of previous midlife estradiol treatment permanently alters interactions of brain insulin-like growth factor-1 signaling and hippocampal estrogen synthesis to enhance cognitive aging in a rat model of menopause
Nina E. Baumgartner, Shannon M. McQuillen, Samantha F. Perry, Sangtawan Miller, Matthieu J. Maroteaux, Robert B. Gibbs, Jill M. Daniel
The paper shows that short-term estradiol treatment after menopause in rats enhances cognitive aging by maintaining hippocampal estrogen receptor function through interactions with IGF-1 and neuroestrogen signaling.
Journal of Neuroscience · Sep 6, 2022Peer-reviewedNeuroscience