A Dose-Response Model for Accurate Detection and Quantification of Transcriptome-Wide Gene Knockdown for Oligonucleotide-Based Medicines
David Pekker, Steven Kuntz, Monica McArthur, T. Nicholson-Shaw, Sara Yanke, Swagatam Mukhopadhyay
The paper develops a dose-response model and analysis tool to accurately quantify gene knockdown effects of oligonucleotide-based medicines using next-generation sequencing data.
bioRxiv · May 28, 2024 · PreprintPharmacology & Toxicology