Inhibition of Cyp1a Protects Mice against Anthracycline Cardiomyopathy
Jing Liu, Casie Curtin, Rahul Lall, Sarah Lane, Jakob Wieke, Abul Ariza, Leinal Sejour, Ioannis S. Vlachos, Beshay N. M. Zordoky, Randall Theodore Peterson, Aarti H. Asnani
This study shows that inhibiting Cyp1a protects mice from anthracycline-induced cardiomyopathy by reducing cardiac dysfunction and altering gene expression related to mitophagy and inflammation.
bioRxiv · Apr 10, 2024 · PreprintMolecular Biology