Integrated cell type-specific analysis of blood and gut identifies matching eQTL for 140 IBD risk loci and entrectinib as possible repurposing candidate.
Hélène Perée, В. А. Петров, Yumie Tokunaga, Alex Kvasz, Sophie Vieujean, Sarah Regimont, Myriam Mni, Marie Wéry, Samira Azarzar, Sophie Jacques, Nicolas Fouillien, Latifa Karim, Manon Deckers, Émilie Detry, Alice Mayer, , Souad Rahmouni
The paper identifies 140 IBD risk loci with matching eQTL in blood and gut tissues and suggests entrectinib as a potential repurposing drug.
medRxiv · Oct 14, 2024 · PreprintGenetic & Genomic Medicine