Antigen-processing rewiring expose cryptic self promoting organ-specific autoimmunity
Astrid Brix Saksager, Sarah Rosenberg Asmussen, Freja Dahl Hede, Carolina Barra
The paper identifies two distinct mechanisms of autoimmunity: altered antigen processing exposing cryptic self-antigens and breakdown of tolerance toward normally presented self-antigens.
bioRxiv · Mar 27, 2026 · PreprintBioinformatics