Astrid Brix Saksager

The paper identifies two distinct mechanisms of autoimmunity: altered antigen processing exposing cryptic self-antigens and breakdown of tolerance toward normally presented self-antigens.

The paper introduces HLAAssoc-1.0 to infer HLA-DRB3/4/5 alleles from HLA-DRB1 data, improving allele and motif deconvolutions in immunopetidomics and training of binding prediction models.

The paper introduces Moonlight2, an updated framework that uses mutation-based mechanistic indicators to identify driver genes in cancer, applied to Basal-like breast cancer.