A protective hybrid protein vaccine informed by mapping major histocompatibility class II epitopes in Cryptococcus neoformans chitin deacetylases that stimulate CD4+ T cell responses
Charles A. Specht, Lorena V. N. Oliveira, Diana Carlson, Maureen M. Hester, Satya Ranjan Sahu, Gabriel Kristian Pedersen, Stuart M. Levitz
The paper identifies MHC-II epitopes in C. neoformans chitin deacetylases that stimulate CD4+ T cells and demonstrates their protective role in a hybrid protein vaccine.
bioRxiv · Sep 14, 2026 · PreprintImmunology