Diana Carlson

Identification of Cryptococcus neoformans capsule-associated protein antigens that mediate B cell-dependent vaccine protection in mice and elicit antibody responses in humans with cryptococcosis

This study identifies Blp4 as a Cryptococcus neoformans antigen that elicits B cell-dependent protective immunity in mice and antibody responses in human cryptococcosis survivors.

A protective hybrid protein vaccine informed by mapping major histocompatibility class II epitopes in Cryptococcus neoformans chitin deacetylases that stimulate CD4+ T cell responses

The paper identifies MHC-II epitopes in C. neoformans chitin deacetylases that stimulate CD4+ T cells and demonstrates their protective role in a hybrid protein vaccine.

Immunological correlates of protection mediated by a whole organism Cryptococcus neoformans vaccine deficient in chitosan

This paper identifies CD4+ T cells and their cytokines IFNγ, TNF, and IL-23 as critical for vaccine-mediated protection against Cryptococcus neoformans, with protection retained after vaccination even with CD4+ T cell depletion.

Protection against experimental cryptococcosis elicited by Cationic Adjuvant Formulation 01-adjuvanted subunit vaccines

This paper develops multivalent cryptococcal vaccines using CAF01 adjuvant that protect mice from experimental cryptococcosis by inducing IFNγ and IL-17 responses.