Neuronopathic GBA1 L444P mutation accelerates glucosylsphingosine levels and formation of hippocampal alpha-synuclein inclusions
Casey L. Mahoney-Crane, Megha Viswanathan, Drèson L. Russell, Rachel A.C. Curtiss, Jennifer Freire, Sai Sumedha Bobba, Sean D. Coyle, Monika Kandebo, Lihang Yao, Bang-Lin Wan, Nathan Galen Hatcher, Sean M. Smith, Jacob Marcus, Laura A. Volpicelli‐Daley
This study shows that the GBA1 L444P mutation increases glucosylsphingosine levels and hippocampal alpha-synuclein inclusions in mice, contributing to synucleinopathy pathology.
Journal of Neuroscience · Dec 7, 2022Peer-reviewedNeuroscience