On the (un-)predictability of a large intragenic fitness landscape
Claudia Bank, Sebastian Matuszewski, Ryan T. Hietpas, Jeffrey D. Jensen
The paper analyzes a large multi-allelic fitness landscape in yeast Hsp90 to assess the predictability of evolution, finding local ruggedness and epistatic hotspots hinder extrapolation.
bioRxiv · Sep 25, 2016Evolutionary Biology