Noninvasive prenatal detection of fetal trisomy and single gene disease by shotgun sequencing of placenta originated exosome DNA: a proof-of-concept validation
Weiting Zhang, Sen Lu, Jia Zhao, Dandan Pu, Haiping Zhang, Lin Yang, Peng Zeng, Fengxia Su, Zhichao Chen, Mei Guo, Ying Gu, Yanmei Luo, Huamei Hu, Yanping E. Lu, Hong‐Yun Zhang, , Ya Ming Gao
This study validates the use of exosomal DNA from maternal plasma for noninvasive prenatal detection of fetal trisomy and single gene disease.
bioRxiv · Nov 7, 2018 · PreprintGenetics